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Product Information

Motilin Receptor Agonist

Compound Code RQ-00201894
Primary Target Indications GI motility disorders (gastroparesis, post-operative Ileus, and functional dyspepsia, etc.)
Development Stage Pre-clinical
Portfolio for global development, manufacturing, and marketing rights
Product Summary Motilin is a GI peptide hormone that regulates migrating motor contractions of the GI tract, thereby playing a crucial role in maintaining gut homeostasis. This compound is an orally-bioavailable small molecule with the strongest agonistic activity and highest selectivity at the motilin receptor among the compounds currently in development. Moreover, RQ-00201894 markedly improved hypo-motility in a dog model of gastric motor dysfunction by oral administration. The motilin receptor agonist is expected to be a breakthrough drug and meet an unsatisfied medical need for treatments of gastroparesis, postoperative ileus, functional dyspepsia and other diseases caused by gastrointestinal motility disorder.

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