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Product Information

5-HT4 Partial Agonist (RQ-00000010)

Compound Code RQ-00000010
Primary Target Indications Functional GI disorder
Development Stage Phase 1 (UK)
Portfolio for global development, manufacturing, and marketing rights
Product Summary Serotonin 5-HT4 receptor is known to have an important role in improving gastrointestinal motility.  RQ-00000010 has been successfully discovered in RaQualia Pharma as a compound with fewer cardiovascular adverse events associated with the conventional 5-HT4 agonists.  In non-clinical studies, strong pharmacological activity and high safety profiles of RQ-00000010 have been confirmed in animals.  In Phase I clinical trial, its excellent safety/tolerability and pharmacokinetic profiles of RQ-00000010 were also confirmed as expected.  Of note is that the strong efficacy on accelerated gastric emptying has been demonstrated in human as well. Therefore, RQ-00000010 could be a safe and therapeutically-effective drug for functional GI disorder such as gastroparesis and functional dyspepsia as well as chronic constipation and other indications caused by impaired gastrointestinal motility.

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